Could the 1st Hokage in Naruto Have been Killed Despite his Overpowering Strength?

Despite being one of the most strongest and important characters in the series, the reason for the Death of the 1st Hokage, Hashirama Senju is still unknown.

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Naruto gets folded by an illness tomorrow, who's becoming the 8th Hokage? : r/Naruto

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Since the previous 3 hokage are still alive and well, what according to you is the appropriate time for appointing the 8th hokage : r/Boruto

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